Targeting Bcl-xL enhances the cytotoxicity of chemotherapeutics
نویسندگان
چکیده
منابع مشابه
Targeting Bcl-2/Bcl-XL Induces Antitumor Activity in Uveal Melanoma Patient-Derived Xenografts
PURPOSE Uveal melanoma (UM) is associated with a high risk of metastases and lack of efficient therapies. Reduced capacity for apoptosis induction by chemotherapies is one obstacle to efficient treatments. Human UM is characterized by high expression of the anti-apoptotic protein Bcl-2. Consequently, regulators of apoptosis such as Bcl-2 family inhibitors may constitute an attractive approach t...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2008
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.7.1.5571